Sck rabbit pAb - 50 μL

Domain: The PID domain mediates binding to the TrkA receptor. function: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. miscellaneous: PubMed: 15057824 has shown that SHC2 is poorly phosphorylated by the Trk receptors, in opposite to PubMed: 12006576. PTM: Phosphorylated on tyrosines by the Trk receptors. similarity: Contains 1 PID domain. similarity: Contains 1 SH2 domain. subunit: Interacts with the Trk receptors in a phosphotyrosine-dependent manner and MEGF12. Once activated, binds to GRB2. tissue specificity: Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.