CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) (CFTR/1643) , CF488A conjugate , 0.1mg / mL

This antibody recognizes a protein of 165-170 kDa , identified as cystic fibrosis transmembrane conductance regulator (CFTR). CFTR is composed of two membrane-spanning domains (MSD) , two nucleotide-binding domains (NBD) , and an R domain. It is structurally similar to multidrug resistance (Mdr1) protein and both are members of the superfamily of ATP-binding cassette (ABC) transporters , also known as traffic ATPases , which are implicated in the movement of various substrates. The CFTR protein is a small conductance adenosine 3' , 5'-cyclic monophosphate (cAMP)-activated chloride ion channel found in the apical membranes of epithelia within the pancreas , airway , intestine , bile duct , sweat gland , and male genital ducts. CFTR is a valuable marker of human pancreatic duct cell development and differentiation.Primary antibodies are available purified , or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets , because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.