LC3 A/B rabbit pAb - 50 μL

Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. similarity: Belongs to the MAP1 LC3 family. subcellular location: LC3-II binds to the autophagic membranes. subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. tissue specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.